1.
Article
in English
| IMSEAR
| ID: sea-159683
Subject(s)
Doxepin/administration & dosage , Doxepin/antagonists & inhibitors , Doxepin/pharmacokinetics , Doxepin/pharmacology , Doxepin/therapeutic use , Adult , Humans , Hypnotics and Sedatives/administration & dosage , Hypnotics and Sedatives/antagonists & inhibitors , Hypnotics and Sedatives/pharmacokinetics , Hypnotics and Sedatives/pharmacology , Hypnotics and Sedatives/therapeutic use
2.
Rev. chil. dermatol
;
14(2): 108-10, 1998.
Article
in Spanish
| LILACS
| ID: lil-231606
3.
Article
in English
| IMSEAR
| ID: sea-19572
ABSTRACT
The in vitro effect of doxepin at 10, 50 and 200 micrograms/mg protein on Mg2+ and (Na+ K+)-ATPases (EC 3.6.1.3) activities of human foetal and adult brain (crude homogenate of cerebrum and cerebellum) were studied at 10-30 wk of gestation. Both Mg2+ and (Na+, K+)-ATPases of human foetal and adult brain were found to be inhibited by doxepin in a dose dependent manner. The inhibitory effect neither varied with respect to the region (i.e., cerebrum and cerebellum) nor with the gestational ages. Inhibition of ATPases activity by doxepin may affect the release and uptake of biogenic amines in the CNS, which may hamper the maturation of brain.